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Q13133 of Proteins NR C4-type domain repeats
Uniprot ID:Q13133
Protein name: Oxysterols receptor LXR-alpha
Gene : NR1H3 LXRA
Protein Family:"Nuclear hormone receptor family, NR1 subfamily"
Squence Length : 447
Sequnce
>Q13133 448 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
NR C4-type domains repeats
ZN_FING 98 118 NR C4-type ZN_FING 134 158 NR C4-type
Domin repeated regions
98 - 118 CSVCGDKASGFHYNVLSCEGC 134 - 158 CHSGGHCPMDTYMRRKCQECRLRKC
Function
"Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity)"
Mutation
268 273 IVDFAK->EVDFAE: Abolishes interaction with NCOA2 without affecting interaction with GPS2 when associated with 438-A-A-439 438 439 LL->AA: Abolishes interaction with NCOA2 without affecting interaction with GPS2 when associated with 268-A--A-273