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Q8IWS0 of Proteins PHD-type domain repeats

Uniprot ID:Q8IWS0	Protein name: PHD finger protein 6	Gene : PHF6 CENP-31 KIAA1823
Protein Family:	Squence Length : 365

Sequnce	>Q8IWS0 366 MSSSVEQKKGPTRQRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEESFNEHELEPSSPKSKKKSRKGRPRKTNFKGLSEDTRSTSSHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGKVEIDQQQLTQQQLNGN
PHD-type domains repeats	ZN_FING 14 52 C2HC pre-PHD-type 1 ZN_FING 80 132 PHD-type 1 ZN_FING 209 249 C2HC pre-PHD-type 2 ZN_FING 278 330 PHD-type 2
Domin repeated regions	14 - 52 QRKCGFCKSNRDKECGQLLISENQKVAAHHKCMLFSSAL 80 - 132 LMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHK 209 - 249 RPKCGFCHVGEEENEARGKLHIFNAKKAAAHYKCMLFSSGT 278 - 330 MKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHS
Function	Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription
Motifs	MOTIF 13 16 Nuclear localization signal. MOTIF 129 133 Nuclear localization signal. MOTIF 157 169 Nucleolar localization signal
Disease	"DISEASE: Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM:301900]: A X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears Note=The disease is caused by mutations affecting the gene represented in this entry"