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Q92731 of Proteins NR C4-type domain repeats
Uniprot ID:Q92731
Protein name: Estrogen receptor beta
Gene : ESR2 ESTRB NR3A2
Protein Family:"Nuclear hormone receptor family, NR3 subfamily"
Squence Length : 530
Sequnce
>Q92731 531 MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
NR C4-type domains repeats
ZN_FING 149 169 NR C4-type ZN_FING 185 209 NR C4-type
Domin repeated regions
149 - 169 CAVCSDYASGYHYGVWSCEGC 185 - 209 CPATNQCTIDKNRRKSCQACRLRKC
Function
"Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual"
Mutation
87 87 S->A: Enhances repression by activated ErbB2/ErbB3 when associated with A-105 87 87 S->D: Abolishes repression by activated ErbB2/ErbB3 when associated with D-105 105 105 S->A: Enhances repression by activated ErbB2/ErbB3 when associated with A-87 105 105 S->D: Abolishes repression by activated ErbB2/ErbB3 when associated with D-87