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Q96K80 of Proteins C3H1-type domain repeats
Uniprot ID:Q96K80
Protein name: Zinc finger CCCH domain-containing protein 10
Gene : ZC3H10 ZC3HDC10
Protein Family:
Squence Length : 434
Sequnce
>Q96K80 435 MPDRDSYANGTGSSGGGPGGGGSEEASGAGVGSGGASSDAICRDFLRNVCKRGKRCRYRHPDMSEVSNLGVSKNEFIFCHDFQNKECSRPNCRFIHGSKEDEDGYKKTGELPPRLRQKVAAGLGLSPADLPNGKEEVPICRDFLKGDCQRGAKCKFRHLQRDFEFDARGGGGTGGGSTGSVLPGRRHDLYDIYDLPDRGFEDHEPGPKRRRGGCCPPDGPHFESYEYSLAPPRGVECRLLEEENAMLRKRVEELKKQVSNLLATNEVLLEQNAQFRNQAKVITLSSTAPATEQTLAPTVGTVATFNHGIAQTHTTLSSQALQPRPVSQQELVAPAGAPAAPPTNAAPPAAPPPPPPHLTPEITPLSAALAQTIAQGMAPPPVSMAPVAVSVAPVAPVAVSMAQPLAGITMSHTTTPMVTYPIASQSMRITAMPH
C3H1-type domains repeats
ZN_FING 36 63 C3H1-type 1 ZN_FING 73 99 C3H1-type 2 ZN_FING 134 161 C3H1-type 3
Domin repeated regions
36 - 63 ASSDAICRDFLRNVCKRGKRCRYRHPDM 73 - 99 KNEFIFCHDFQNKECSRPNCRFIHGSK 134 - 161 KEEVPICRDFLKGDCQRGAKCKFRHLQR
Function
"Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA"
Mutation
50 56 CKRGKRC->SKRGKRS: Abolishes binding to pri-MIR143 87 92 CSRPNC->SSRPNS: Abolishes binding to pri-MIR143 148 154 CQRGAKC->SQRGAKS: Reduces binding to pri-MIR143