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Q9HBF4 of Proteins FYVE-type domain repeats
Uniprot ID:Q9HBF4
Protein name: Zinc finger FYVE domain-containing protein 1
Gene : ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436
Protein Family:
Squence Length : 777
Sequnce
>Q9HBF4 778 MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHERIRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTVYNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL
FYVE-type domains repeats
ZN_FING 598 659 FYVE-type 1 ZN_FING 715 775 FYVE-type 2
Domin repeated regions
598 - 659 NSQILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARN 715 - 775 DHEILHCHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPG
Mutation
616 616 T->R: Partially restore PtdIns3P binding when associated with R-733 617 617 K->A: Drastically reduce PtdIns3P binding when associated with A-619 and A-621 when associated with A-734 A-736 and A-738 619 619 H->A: Drastically reduce PtdIns3P binding when associated with A-617 and A-621 when associated with A-734 A-736 and A-738 621 621 R->A: Drastically reduce PtdIns3P binding when associated with A-617 and A-619 when associated with A-734 A-736 and A-738 654 654 C->S: Abolishes PtdIns3P binding when associated with S-770 733 733 S->R: Partially restored PtdIns3P binding when associated with R-616 734 734 K->A: Drastically reduce PtdIns3P binding when associated with A-736 and A-738 when associated with A-617 A-619 and A-621 736 736 H->A: Drastically reduce PtdIns3P binding when associated with A-734 and A-738 when associated with A-617 A-619 and A-621 738 738 R->A: Drastically reduce PtdIns3P binding when associated with A-734 and A-736 when associated with A-617 A-619 and A-621 770 770 C->S: Abolishes PtdIns3P binding when associated with S-654