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Q9NQ86 of Proteins B box-type domain repeats
Uniprot ID:Q9NQ86
Protein name: E3 ubiquitin-protein ligase TRIM36
Gene : TRIM36 RBCC728 RNF98
Protein Family:TRIM/RBCC family
Squence Length : 728
Sequnce
>Q9NQ86 729 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
B box-type domains repeats
ZN_FING 33 84 RING-type ZN_FING 154 192 B box-type 1 ZN_FING 207 249 B box-type 2
Domin repeated regions
154 - 192 AIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTI 207 - 249 PKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTM
Function
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization
Disease
"DISEASE: Anencephaly (ANPH) [MIM:206500]: An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level The skull is only partially formed ANPH inheritance is autosomal recessive Note=The disease is caused by mutations affecting the gene represented in this entry"