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Q9NUK0 of Proteins C3H1-type domain repeats
Uniprot ID:Q9NUK0
Protein name: Muscleblind-like protein 3
Gene : MBNL3 CHCR MBLX39 MBXL
Protein Family:Muscleblind family
Squence Length : 354
Sequnce
>Q9NUK0 355 MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF
C3H1-type domains repeats
ZN_FING 14 42 C3H1-type 1 ZN_FING 48 74 C3H1-type 2 ZN_FING 174 202 C3H1-type 3 ZN_FING 210 236 C3H1-type 4
Domin repeated regions
14 - 42 WLTLEVCREFQRGTCSRADADCKFAHPPR 48 - 74 NGRVVACFDSLKGRCTRENCKYLHPPP 174 - 202 SDKLEVCREFQRGNCTRGENDCRYAHPTD 210 - 236 DNTVTICMDYIKGRCSREKCKYFHPPA
Function
"Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction"