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Q9UBS8 of Proteins RING-type domain repeats

Uniprot ID:Q9UBS8	Protein name: E3 ubiquitin-protein ligase RNF14	Gene : RNF14 ARA54 HRIHFB2038
Protein Family:"RBR family, RNF14 subfamily"	Squence Length : 474

Sequnce	>Q9UBS8 475 MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED
RING-type domains repeats	ZN_FING 220 270 RING-type 1 ZN_FING 289 350 IBR-type ZN_FING 404 433 RING-type 2
Domin repeated regions	220 - 270 CSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKC 404 - 433 CPCCGTPIEKLDGCNKMTCTGCMQYFCWIC
Function	"Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription"
Active Site	ACT_SITE 417 417
Motifs	MOTIF 37 45 D-box
Mutation	220 220 C->S: Loss of interaction with UBE2E2 and of autoubiquitination