Uniprot ID:Q9UGL1	Protein name: Lysine-specific demethylase 5B	Gene : KDM5B JARID1B PLU1 RBBP2H1
Protein Family:JARID1 histone demethylase family	Squence Length : 1544

Sequnce	>Q9UGL1 1545 MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEFDVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWDNRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK
PHD-type domains repeats	ZN_FING 309 359 PHD-type 1 ZN_FING 692 744 C5HC2 ZN_FING 1176 1224 PHD-type 2 ZN_FING 1484 1538 PHD-type 3
Domin repeated regions	309 - 359 LYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQ 1176 - 1224 IKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRIWLCPHCRRS 1484 - 1538 DAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVK
Function	"Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)"
Binding Site	BINDING 425 425 2-oxoglutarate. BINDING 507 507 2-oxoglutarate. BINDING 509 509 2-oxoglutarate. BINDING 517 517 2-oxoglutarate
Mutation	308 308 D->A: Slightly decreases interaction with histone H3 309 309 L->A: No effect on interaction with histone H3 310 310 Y->A: Slightly decreases interaction with histone H3 310 310 Y->F: No effect on interaction with histone H3 311 311 V->A: No effect on interaction with histone H3 321 321 E->A: Decreases interaction with histone H3 322 322 D->A: No effect on interaction with histone H3 324 324 L->A: No effect on interaction with histone H3 325 325 L->A: Abolishes interaction with histone H3 when associated with A-328 326 326 L->A: No effect on interaction with histone H3 328 328 D->A: Almost abolishes interaction with histone H3 when associated with A-325 332 332 D->A: No effect on interaction with histone H3 333 333 S->A: No effect on interaction with histone H3 334 334 Y->A: No effect on interaction with histone H3 335 335 H->A: Slightly impairs transcription repression ability 345 345 D->A: No effect on interaction with histone H3 351 351 W->A: Abolishes interaction with histone H3 499 501 HIE->AIA: Abolishes lysine-specific histone demethylase activity 499 499 H->Y: Abolishes lysine-specific histone demethylase activity 1200 1200 H->A: Impairs transcription repression ability and interaction with HDAC4

Q9UGL1 of Proteins PHD-type domain repeats