| S.NO | Uniprot ID | Protein Name | Sequence Length | ACT Region | Mutation | Involvement of Repeats in Mutations |
| 1 | Q8WTX7 | Cytosolic arginine sensor for mTORC1 subunit 1 | 329 | 90 90 Q->A: No effect on interaction with the GATOR2 complex 96 96 K->A: No effect on interaction with the GATOR2 complex 99 99 R->A: No effect on interaction with the GATOR2 complex 108 110 108 110 HHV->QNI: Loss of arginine-binding 111 111 S->A: Loss of arginine-binding 113 113 L->F: No effect on interaction with the GATOR2 complex 118 119 118 119 YQ->AA: No effect on arginine-binding 121 121 D->A: No effect on arginine-binding 126 126 R->A: Decreased arginine-binding 175 175 H->A: Decreased arginine-binding 202 202 I->E: No effect on arginine-binding 207 207 Y->S: No effect on arginine-binding 261 261 E->A: No effect on arginine-binding 264 264 R->A: No effect on interaction with the GATOR2 complex 276 276 D->A: Decreased arginine-binding 277 277 E->A: Decreased arginine-binding 278 278 C->A: Decreased arginine-binding 280 280 I->A: Loss of arginine-binding 292 292 D->A: No effect on arginine-binding 302 302 N->K: No effect on interaction with the GATOR2 complex 304 304 D->A: Loss of arginine-binding | Y | |