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The 2 GoLoco Repeats and their Mutations

S.NOUniprot IDProtein Name Sequence LengthGoLoco RegionMutationInvolvement of Repeats in Mutations
1 P81274 G-protein-signaling modulator 2 684228 228 R->A: Abolishes location at mitotic spindle poles
when associated with A-243
228 228 R->E: Strongly reduces interaction with INSC
when associated with R-290
243 243 R->A: Abolishes location at mitotic spindle poles
when associated with A-228
290 290 N->R: Abolishes interaction with INSC
when associated with E-228
N
2 Q9Y4H4 G-protein-signaling modulator 3 160121 121 A->D: Restores G(i) alpha binding and GDI activity of the GoLoco 2 domain
Y