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Details of 1 PXXXP Repeats and their Mutations

S.NOUniprot ID Protein Name Sequence LengthPXXXP Repeats regionMutationsInvolvement of Repeats in Mutations
1 Q8TD08 Mitogen-activated protein kinase 15 54442 42 K->A: Not phosphorylated at Thr-175 and Tyr-177
42 42 K->R: Loss of autophosphorylation and activity
59 59 R->Q: Does not increase dopamine transporter activity
155 155 D->A: Unable to induce the formation of autophagosomal structures
175 175 T->A: Loss of autophosphorylation and activity
when associated with F-177
177 177 Y->A: Loss of autophosphorylation and activity
177 177 Y->F: Does not rescues inhibition of O-glycosylation in MAPK15-depleted cells
when associated with A-175
265 269 LDALL->ADAAA: Markedly decreases interaction with ESRRA
when associated with A-281 and 284-A--A-285
281 285 LRRLL->ARRAA: Markedly decreases interaction with ESRRA
when associated with A-265 and 268-A--A-269
300 300 Q->A: Impairs interaction with PCNA
340 343 YQMI->AQMA: Impairs interaction with GABARAP and MAP1LC3B
390 390 P->A: Impairs chromatin binding
when associated with A-398
when associated with A-398
398 398 P->A: Impairs chromatin binding
when associated with A-390
when associated with A-390
Y