S.NO | Uniprot ID | Protein Name | Sequence Length | PXXXP Repeats region | Mutations | Involvement of Repeats in Mutations |
1 | Q8TD08 | Mitogen-activated protein kinase 15 | 544 | 42 42 K->A: Not phosphorylated at Thr-175 and Tyr-177 42 42 K->R: Loss of autophosphorylation and activity 59 59 R->Q: Does not increase dopamine transporter activity 155 155 D->A: Unable to induce the formation of autophagosomal structures 175 175 T->A: Loss of autophosphorylation and activity when associated with F-177 177 177 Y->A: Loss of autophosphorylation and activity 177 177 Y->F: Does not rescues inhibition of O-glycosylation in MAPK15-depleted cells when associated with A-175 265 269 LDALL->ADAAA: Markedly decreases interaction with ESRRA when associated with A-281 and 284-A--A-285 281 285 LRRLL->ARRAA: Markedly decreases interaction with ESRRA when associated with A-265 and 268-A--A-269 300 300 Q->A: Impairs interaction with PCNA 340 343 YQMI->AQMA: Impairs interaction with GABARAP and MAP1LC3B 390 390 P->A: Impairs chromatin binding when associated with A-398 when associated with A-398 398 398 P->A: Impairs chromatin binding when associated with A-390 when associated with A-390 | Y |