| S.NO | Uniprot ID | Protein Name | Sequence Length | FZ Repeated Region | Function |
| 1 | Q9Y5Q5 | Atrial natriuretic peptide-converting enzyme | 1042 | "Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. ; Isoform 2: has weaker endopeptidase activity compared to isoform 1". |