| S.NO | Uniprot ID | Protein Name | Sequence Length | GoLoco Repeated Region | Function |
| 1 | Q8IVA1 | Purkinje cell protein 2 homolog | 136 | May function as a cell-type specific modulator for G protein-mediated cell signaling. | |
| 2 | P81274 | G-protein-signaling modulator 2 | 684 | "Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity)". | |
| 3 | Q86YR5 | G-protein-signaling modulator 1 | 675 | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. | |
| 4 | Q9Y4H4 | G-protein-signaling modulator 3 | 160 | Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins. |