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The 3 CXXCXGXG Repeats proteins and their functions

S.NO	Uniprot ID	Protein Name	Sequence Length	CXXCXGXG Repeats region	Function
1	P31689	DnaJ homolog subfamily A member 1	397	REPEAT 134 141 CXXCXGXG motif REPEAT 150 157 CXXCXGXG motif REPEAT 177 184 CXXCXGXG motif REPEAT 193 200 CXXCXGXG motif	"Co-chaperone for HSPA8/Hsc70 (PubMed:10816573) Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877) Plays a role in protein transport into mitochondria via its role as co-chaperone Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510) Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202)"
2	O60884	DnaJ homolog subfamily A member 2	412	REPEAT 143 150 CXXCXGXG motif REPEAT 159 166 CXXCXGXG motif REPEAT 186 193 CXXCXGXG motif REPEAT 202 209 CXXCXGXG motif	Co-chaperone of Hsc70 Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877)
3	Q96EY1	"DnaJ homolog subfamily A member 3, mitochondrial "	480	REPEAT 236 243 CXXCXGXG motif REPEAT 253 260 CXXCXGXG motif REPEAT 275 282 CXXCXGXG motif REPEAT 289 296 CXXCXGXG motif	"Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis Can modulate IFN-gamma-mediated transcriptional activity Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway"