S.NO	Uniprot ID	Protein Name	Sequence Length	Hemopexin Repeats region	Function
1	P04004	Vitronectin	478	REPEAT 158 202 Hemopexin 1 REPEAT 203 250 Hemopexin 2 REPEAT 251 305 Hemopexin 3 REPEAT 419 472 Hemopexin 4	Vitronectin is a cell adhesion and spreading factor found in serum and tissues Vitronectin interact with glycosaminoglycans and proteoglycans Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway ; Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity
2	P03956	Interstitial collagenase	469	REPEAT 275 324 Hemopexin 1 REPEAT 325 371 Hemopexin 2 REPEAT 374 422 Hemopexin 3 REPEAT 423 466 Hemopexin 4	"Cleaves collagens of types I, II, and III at one site in the helical domain Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757) In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369)"
3	Q9H306	Matrix metalloproteinase-27	513	REPEAT 276 325 Hemopexin 1 REPEAT 326 371 Hemopexin 2 REPEAT 373 421 Hemopexin 3 REPEAT 422 465 Hemopexin 4	"Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens"
4	P22894	Neutrophil collagenase	467	REPEAT 276 325 Hemopexin 1 REPEAT 326 372 Hemopexin 2 REPEAT 374 420 Hemopexin 3 REPEAT 421 464 Hemopexin 4	"Can degrade fibrillar type I, II, and III collagens"
5	P39900	Macrophage metalloelastase	470	REPEAT 279 328 Hemopexin 1 REPEAT 329 375 Hemopexin 2 REPEAT 377 425 Hemopexin 3 REPEAT 426 470 Hemopexin 4	"May be involved in tissue injury and remodeling Has significant elastolytic activity Can accept large and small amino acids at the P1' site, but has a preference for leucine Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3"
6	P45452	Collagenase 3	471	REPEAT 281 330 Hemopexin 1 REPEAT 331 377 Hemopexin 2 REPEAT 379 427 Hemopexin 3 REPEAT 428 471 Hemopexin 4	"Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen Can also degrade collagen type IV, type XIV and type X May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification Required for normal embryonic bone development and ossification Plays a role in the healing of bone fractures via endochondral ossification Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF Plays a role in keratinocyte migration during wound healing May play a role in cell migration and in tumor cell invasion"
7	Q99542	Matrix metalloproteinase-19	508	REPEAT 286 333 Hemopexin 1 REPEAT 334 380 Hemopexin 2 REPEAT 381 425 Hemopexin 3 REPEAT 426 472 Hemopexin 4	"Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease) May also play a role in neovascularization or angiogenesis Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin"
8	P09238	Stromelysin-2	476	REPEAT 286 335 Hemopexin 1 REPEAT 336 382 Hemopexin 2 REPEAT 384 432 Hemopexin 3 REPEAT 433 476 Hemopexin 4	"Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V Activates procollagenase"
9	P08254	Stromelysin-1	477	REPEAT 287 336 Hemopexin 1 REPEAT 337 383 Hemopexin 2 REPEAT 385 433 Hemopexin 3 REPEAT 434 477 Hemopexin 4	"Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans Activates procollagenase"
10	P24347	Stromelysin-3	488	REPEAT 291 339 Hemopexin 1 REPEAT 340 382 Hemopexin 2 REPEAT 384 432 Hemopexin 3 REPEAT 433 480 Hemopexin 4	May play an important role in the progression of epithelial malignancies
11	O60882	Matrix metalloproteinase-20	483	REPEAT 293 343 Hemopexin 1 REPEAT 344 389 Hemopexin 2 REPEAT 391 439 Hemopexin 3 REPEAT 440 483 Hemopexin 4	"Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP) May play a central role in tooth enamel formation Cleaves aggrecan at the '360-Asn-\|-Phe-361' site"
12	Q9NPA2	Matrix metalloproteinase-25	562	REPEAT 314 363 Hemopexin 1 REPEAT 367 412 Hemopexin 2 REPEAT 413 461 Hemopexin 3 REPEAT 462 508 Hemopexin 4	May activate progelatinase A
13	P50281	Matrix metalloproteinase-14	582	REPEAT 316 364 Hemopexin 1 REPEAT 365 410 Hemopexin 2 REPEAT 412 460 Hemopexin 3 REPEAT 461 508 Hemopexin 4	Endopeptidase that degrades various components of the extracellular matrix such as collagen Activates progelatinase A Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity) May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484) Acts as a positive regulator of cell growth and migration via activation of MMP15 Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657) Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140)
14	Q9H239	Matrix metalloproteinase-28	520	REPEAT 325 369 Hemopexin 1 REPEAT 370 409 Hemopexin 2 REPEAT 415 463 Hemopexin 3 REPEAT 464 510 Hemopexin 4	Can degrade casein Could play a role in tissues homeostasis and repair
15	Q8N119	Matrix metalloproteinase-21	569	REPEAT 330 389 Hemopexin 1 REPEAT 391 447 Hemopexin 2 REPEAT 448 496 Hemopexin 3 REPEAT 503 559 Hemopexin 4	"Plays a specialized role in the generation of left-right asymmetry during embryogenesis May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028) Cleaves alpha-1-antitrypsin (PubMed:12617721)"
16	Q9ULZ9	Matrix metalloproteinase-17	603	REPEAT 333 378 Hemopexin 1 REPEAT 382 427 Hemopexin 2 REPEAT 428 475 Hemopexin 3 REPEAT 476 523 Hemopexin 4	"Endopeptidase that degrades various components of the extracellular matrix, such as fibrin May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha May also be involved in tumoral process Cleaves pro-TNF-alpha at the '74-Ala-\|-Gln-75' site Not obvious if able to proteolytically activate progelatinase A Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin"
17	P51512	Matrix metalloproteinase-16	607	REPEAT 340 388 Hemopexin 1 REPEAT 389 434 Hemopexin 2 REPEAT 436 484 Hemopexin 3 REPEAT 485 532 Hemopexin 4	"Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin Activates progelatinase A Involved in the matrix remodeling of blood vessels Isoform short cleaves fibronectin and also collagen type III, but at lower rate It has no effect on type I, II, IV and V collagen However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells"
18	P51511	Matrix metalloproteinase-15	669	REPEAT 367 415 Hemopexin 1 REPEAT 416 461 Hemopexin 2 REPEAT 463 511 Hemopexin 3 REPEAT 512 559 Hemopexin 4	Endopeptidase that degrades various components of the extracellular matrix May activate progelatinase A
19	Q9Y5R2	Matrix metalloproteinase-24	645	REPEAT 377 425 Hemopexin 1 REPEAT 426 471 Hemopexin 2 REPEAT 473 521 Hemopexin 3 REPEAT 522 569 Hemopexin 4	"Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence May play a role in axonal growth Able to activate progelatinase A May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity)"
20	P08253	72 kDa type IV collagenase	660	REPEAT 472 516 Hemopexin 1 REPEAT 517 563 Hemopexin 2 REPEAT 565 613 Hemopexin 3 REPEAT 614 660 Hemopexin 4	"Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction Also cleaves KISS at a Gly-\|-Leu bond Appears to have a role in myocardial cell death pathways Contributes to myocardial oxidative stress by regulating the activity of GSK3beta Cleaves GSK3beta in vitro Involved in the formation of the fibrovascular tissues in association with MMP14 ; PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin Ligand for integrinv/beta3 on the surface of blood vessels ; Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways"
21	P14780	Matrix metalloproteinase-9	707	REPEAT 518 563 Hemopexin 1 REPEAT 564 608 Hemopexin 2 REPEAT 610 657 Hemopexin 3 REPEAT 658 704 Hemopexin 4	May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration Could play a role in bone osteoclastic resorption Cleaves KiSS1 at a Gly-\|-Leu bond Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments Degrades fibronectin but not laminin or Pz-peptide
22	P02790	Hemopexin	462	REPEAT 53 93 Hemopexin 1 REPEAT 94 139 Hemopexin 2 REPEAT 140 184 Hemopexin 3 REPEAT 185 231 Hemopexin 4 REPEAT 259 304 Hemopexin 5 REPEAT 305 352 Hemopexin 6 REPEAT 357 396 Hemopexin 7 REPEAT 400 450 Hemopexin 8	"Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation"

The 22 Hemopexin Repeats proteins and their functions