BACK HOME

The 10 WW Repeats and their Active sites

S.NO	Uniprot ID	Protein Name	Sequence Length	WW Region	Active Site	Involvement of Repeats in Active site
1	Q9HAU4	E3 ubiquitin-protein ligase SMURF2	748	DOMAIN 157 190 WW 1 DOMAIN 251 284 WW 2 DOMAIN 297 330 WW 3	ACT_SITE 716 716 Glycyl thioester intermediate	N
2	Q9HCE7	E3 ubiquitin-protein ligase SMURF1	757	DOMAIN 234 267 WW 1 DOMAIN 306 339 WW 2	ACT_SITE 725 725 Glycyl thioester intermediate	N
3	Q9NZC7	WW domain-containing oxidoreductase	414	DOMAIN 16 49 WW 1 DOMAIN 57 90 WW 2	ACT_SITE 293 293 Proton acceptor	N
4	Q9P2P5	E3 ubiquitin-protein ligase HECW2	1572	DOMAIN 807 840 WW 1 DOMAIN 985 1018 WW 2	ACT_SITE 1540 1540 Glycyl thioester intermediate	N
5	Q76N89	E3 ubiquitin-protein ligase HECW1	1606	DOMAIN 829 862 WW 1 DOMAIN 1018 1051 WW 2	ACT_SITE 1574 1574 Glycyl thioester intermediate	N
6	O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	870	DOMAIN 300 333 WW 1 DOMAIN 330 363 WW 2 DOMAIN 405 437 WW 3 DOMAIN 444 477 WW 4	ACT_SITE 838 838 Glycyl thioester intermediate	N
7	Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	922	DOMAIN 349 382 WW 1 DOMAIN 381 414 WW 2 DOMAIN 456 489 WW 3 DOMAIN 496 529 WW 4	ACT_SITE 890 890 Glycyl thioester intermediate	N
8	Q96J02	E3 ubiquitin-protein ligase Itchy homolog	903	DOMAIN 326 359 WW 1 DOMAIN 358 391 WW 2 DOMAIN 438 471 WW 3 DOMAIN 478 511 WW 4	ACT_SITE 871 871 Glycyl thioester intermediate	N
9	P46934	E3 ubiquitin-protein ligase NEDD4	1319	DOMAIN 610 643 WW 1 DOMAIN 767 800 WW 2 DOMAIN 840 873 WW 3 DOMAIN 892 925 WW 4	ACT_SITE 1286 1286 Glycyl thioester intermediate	N
10	Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	975	DOMAIN 193 226 WW 1 DOMAIN 385 418 WW 2 DOMAIN 497 530 WW 3 DOMAIN 548 581 WW 4	ACT_SITE 942 942 Glycyl thioester intermediate	N