| S.NO | Uniprot ID | Protein Name | Sequence Length | WW Region | Mutation | Involvement of Repeats in Mutations |
| 1 | Q9HAU4 | E3 ubiquitin-protein ligase SMURF2 | 748 | 29 29 F->A: Increases autoubiquitination when associated with A-30 30 30 F->A: Increases autoubiquitination when associated with A-29 56 56 T->A: Increases autoubiquitination when associated with A-57 57 57 L->A: Increases autoubiquitination when associated with A-56 251 284 251 284 Missing: Abolishes interaction with SMAD2 and SMAD7 297 330 297 330 Missing: Abolishes interaction with SMAD7 535 535 W->A: Loss of catalytic activity 535 535 W->D: Loss of catalytic activity 547 547 H->A: Partial loss of catalytic activity 547 547 H->F,I: Activates autocatalytic activity 581 581 Y->A: Loss of catalytic activity 716 716 C->A: Increases Smad7-bound TGF-beta receptors in membrane rafts 716 716 C->G: Loss of activity | Y | |
| 2 | Q9HCE7 | E3 ubiquitin-protein ligase SMURF1 | 757 | 28 28 K->A: Fails to ubiquitinate RHOA when associated with A-85 85 85 K->A: Fails to ubiquitinate RHOA when associated with A-28 350 350 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-381 and R-381 381 381 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-350 and R-383 when associated with R-383 383 383 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-350 and R-381 when associated with R-381 725 725 C->A: Loss of enzyme activity, without abolishing FBXL15-mediated ubiquitination | N | |
| 3 | O75554 | WW domain-binding protein 4 | 376 | 150 150 W->A: Nearly abolishes activation of pre-mRNA splicing 191 191 W->A: Nearly abolishes activation of pre-mRNA splicing | Y | |
| 4 | O14776 | Transcription elongation regulator 1 | 1098 | 148 150
148 150 YYY->AAA: Reduces repression of transcription by 35% when associated with 446-AAA-448 446 448 446 448 YYY->AAA: Loss of interaction with SF1 when associated with 148-AAA-150 545 547 545 547 FFY->AAA: No effect | Y | |
| 5 | Q9NZC7 | WW domain-containing oxidoreductase | 414 | 28 28 K->T: No effect on interaction with TP53 when associated with V-29 29 29 D->V: No effect on interaction with TP53 when associated with T-28 33 33 Y->F: Loss of phosphorylation 33 33 Y->R: Abolishes interaction with TP53, TP73, MAPK8 and ERBB4 44 47 44 47 WEHP->FEHA: Abolishes interaction with LITAF 61 61 Y->R: No effect on interaction with TP73 85 88 85 88 YLDP->ALDA: No effect on interaction with LITAF 287 287 Y->A: Loss of phosphorylation by TNK2 | Y | |
| 6 | P46937 | Transcriptional coactivator YAP1 | 504 | 61 61 S->A: In YAP-4SA prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus when associated with A-109 A-127 and A-164 80 80 V->A: No change in interaction with TEAD4 when associated with A-84 and A-85 84 84 V->A: Reduced interaction with TEAD4 and transforming ability when associated with A-80 and A-85 85 85 P->A: Reduced interaction with TEAD4 and transforming ability when associated with A-80 and A-84 86 86 M->A: Complete loss of interaction with TEAD1 89 89 R->A: Complete loss of interaction with TEAD1 91 91 L->A: Complete loss of interaction with TEAD1 94 94 S->A: Loss of interaction with TEAD1, TEAD2, TEAD3 and TEAD4 95 95 F->A: Complete loss of interaction with TEAD1 96 96 F->A: Loss of interaction with TEAD1 109 109 S->A: In YAP-4SA prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus when associated with A-61 A-127 and A-164 122 122 H->A,R,N,K: Loss of phosphorylation by LATS1 122 122 H->L,Y: Significantly decreased phosphorylation at S-127 and decreased interaction with YWHAB 124 124 R->A: Loss of phosphorylation by LATS1 127 127 S->A: Reduced phosphorylation by LATS2, loss of phosphorylation by LATS1, loss of interaction with YWHAB, decreased interaction with ERBB4 and increased nuclear localization and transcriptional coactivation activity toward ERBB4 prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus when associated with A-61 A-109 A-127 and A-164 129 129 P->D: No effect on phosphorylation but loss of interaction with YWHAB 164 164 S->A: In YAP-4SA prevents phosphorylation by LATS1 and LATS2, promoting retention in the nucleus when associated with A-61 A-109 and A-127 199 199 W->A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF when associated with A-202 202 202 P->A: Loss of interaction with ERBB4 and loss of transcriptional coactivation function toward CTF when associated with A-199 397 397 S->A: Loss of phosphorylation by LATS1 407 407 Y->E: Enhanced interaction with TP73 407 407 Y->F: No phosphorylation by ABL1 and partial loss of binding to TP73 | Y | |
| 7 | O00308 | NEDD4-like E3 ubiquitin-protein ligase WWP2 | 870 | 498 498 K->R: Does not affect FBXL15-mediated ubiquitination 500 500 H->K: Does not affect FBXL15-mediated ubiquitination 838 838 C->A: Abolishes ubiquitination of POU5F1 | N | |
| 8 | O95817 | BAG family molecular chaperone regulator 3 | 575 | 480 481
480 481 RR->AA: Significant loss of interaction with HSPA8 | N | |
| 9 | Q9H0M0 | NEDD4-like E3 ubiquitin-protein ligase WWP1 | 922 | 614 614 E->A: Reduces ubiquitin transfer 621 621 H->A: Strongly reduces ubiquitin transfer 675 675 D->A: Reduces ubiquitin transfer 798 798 E->A: Reduces ubiquitin transfer when associated with A-845 804 804 M->P: Strongly reduces ubiquitin transfer when associated with P-806 806 806 E->P: Strongly reduces ubiquitin transfer when associated with P-804 845 845 R->A: No effect 848 848 Q->A: Abolishes ubiquitin transfer when associated with A-855 855 855 R->A: Abolishes ubiquitin transfer when associated with A-848 | N | |
| 10 | Q96J02 | E3 ubiquitin-protein ligase Itchy homolog | 903 | 343 343 Y->F: No effect on phosphorylation on T-cell stimulation nor in the presence of FYN 420 420 Y->F: Greatly reduced phosphorylation on T-cell stimulation and in the presence of FYN 455 455 Y->F: No effect on phosphorylation on T-cell stimulation nor in the presence of FYN 871 871 C->A: Loss of ubiquitin protein ligase activity | Y | |
| 11 | P46934 | E3 ubiquitin-protein ligase NEDD4 | 1319 | 795 795 W->A: Abolishes interaction with ARRDC3 when associated with A-868 and A-920 868 868 W->A: Abolishes interaction with ARRDC3 when associated with A-795 and A-920 920 920 W->A: Abolishes interaction with ARRDC3 when associated with A-795 and A-868 | Y | |
| 12 | Q96PU5 | E3 ubiquitin-protein ligase NEDD4-like | 975 | 448 448 S->A: Abolishes interaction with 1433F 942 942 C->S: Abolishes activity | N | |