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The 18 function of CBS of the protein

S.NOUniprot IDProtein Name Sequence LengthCBS Repeated RegionFunction
1 P20839 Inosine-5'-monophosphate dehydrogenase 1 514"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.
It may also have a role in the development of malignancy and the growth progression of some tumors".
2 P12268 Inosine-5'-monophosphate dehydrogenase 2 514"Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.
It may also have a role in the development of malignancy and the growth progression of some tumors".
3 Q8NE01 Metal transporter CNNM3 707Probable metal transporter.
4 Q6P4Q7 Metal transporter CNNM4 775Probable metal transporter.
The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity).
May play a role in biomineralization and retinal function.
5 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 489"AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.
In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.
Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.
ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive".
6 Q9NRU3 Metal transporter CNNM1 951Probable metal transporter.
7 Q9H8M5 Metal transporter CNNM2 875Divalent metal cation transporter.
Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).
8 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 569"AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.
In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.
Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.
ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive".
9 P54619 5'-AMP-activated protein kinase subunit gamma-1 331"AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.
In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.
Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.
ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive".
10 P51800 Chloride channel protein ClC-Ka 687"Voltage-gated chloride channel.
Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
May be important in urinary concentrating mechanisms".
11 P51801 Chloride channel protein ClC-Kb 687"Voltage-gated chloride channel.
Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
May be important in urinary concentrating mechanisms".
12 P51788 Chloride channel protein 2 898"Voltage-gated chloride channel.
Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport".
13 P51795 H(+)/Cl(-) exchange transporter 5746Proton-coupled chloride transporter.
Functions as antiport system and exchanges chloride ions against protons.
Important for normal acidification of the endosome lumen.
May play an important role in renal tubular function.
14 P51793 H760Proton-coupled chloride transporter.
Functions as antiport system and exchanges chloride ions against protons.
15 P51797 Chloride transport protein 6 869"Chloride transport protein, initially identified as voltage-gated chloride channel.
The presence of the conserved gating glutamate residues suggests that is functions as antiporter".
16 P35523 Chloride channel protein 1 988"Voltage-gated chloride channel.
Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport".
17 P51798 H(+)/Cl(-) exchange transporter 7805Slowly voltage-gated channel mediating the exchange of chloride ions against protons.
Functions as antiporter and contributes to the acidification of the lysosome lumen.
18 P51790 H(+)/Cl(-) exchange transporter 3818"Mediates the exchange of chloride ions against protons.
Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis.
May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.
It could help neuronal cells to establish short-term memory".