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The 15 function of UIM of the protein

S.NOUniprot IDProtein Name Sequence LengthUIM Repeated RegionFunction
1 Q9H3M9 Ataxin-3-like protein 355Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).
2 P54252 Ataxin-3 361"Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278).
Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782).
Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).
Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501).
Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460)".
3 Q9Y6I3 Epsin-1 576"Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity).
Regulates receptor-mediated endocytosis".
4 O95208 Epsin-2 641Plays a role in the formation of clathrin-coated invaginations and endocytosis.
5 Q9UHP3 Ubiquitin carboxyl-terminal hydrolase 25 1055"Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates.
Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.
; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function".
6 P42566 Epidermal growth factor receptor substrate 15 896"Involved in cell growth regulation.
May be involved in the regulation of mitogenic signals and control of cell proliferation.
Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR.
Plays a role in the assembly of clathrin-coated pits (CCPs).
Acts as a clathrin adapter required for post-Golgi trafficking.
Seems to be involved in CCPs maturation including invagination or budding.
Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2".
7 Q8WV99 AN1-type zinc finger protein 2B 257"Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum.
It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum.
It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed.
May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)".
8 P25686 DnaJ homolog subfamily B member 2 324"Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199).
In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).
Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).
Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278)".
9 A2A3N6 Putative PIP5K1A and PSMD4-like protein 862Has negligible PIP5 kinase activity.
Binds to ubiquitinated proteins.
10 Q86T82 Ubiquitin carboxyl-terminal hydrolase 37 979"Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry.
Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex.
Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro.
Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315).
Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872)".
11 Q6ZTN6 Ankyrin repeat domain-containing protein 13D518Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.
Does not bind 'Lys-48'-linked ubiquitin.
Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
12 Q8IZ07 Ankyrin repeat domain-containing protein 13A 590Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.
Does not bind 'Lys-48'-linked ubiquitin.
Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
13 P55036 26S proteasome non-ATPase regulatory subunit 4 377"Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction.
Displays a preferred selectivity for longer polyubiquitin chains".
14 Q86YJ7 Ankyrin repeat domain-containing protein 13B626Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin.
Does not bind 'Lys-48'-linked ubiquitin.
Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
15 Q96RL1 BRCA1-A complex subunit RAP80 719"Ubiquitin-binding protein (PubMed:24627472).
Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.
37).
Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).
The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin.
May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo.
Does not bind Lys-48'-linked ubiquitin.
May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
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